Scientist Method Development Chromatography

As a Scientist at Anabiotec, you will act as a scientific lead in the analytical lifecycle of (bio)-pharmaceutical products. Your mission is to bridge the gap between complex client needs and robust laboratory solutions.

• Design, optimize, and troubleshoot complex chromatographic methods (primarily HPLC/UPLC) for a diverse portfolio, including small molecules, peptides, oligonucleotides, and proteins/antibodies.

• You will act as the Subject Matter Expert (SME) for Liquid Chromatography guiding the lab team through technical hurdles.

• Interact with international biopharma clients to define analytical strategies, discuss scientific data, and provide expert advice on regulatory requirements.

• You lead the transition of methods from development to qualification and validation, ensuring they are "fit-for-purpose" according to ICH guidelines.

• Uphold the highest standards of data integrity. Ensure all work is documented and reported according to Good Documentation Practices (GDocP) and within the framework of GLP/GMP environments where required.

• Innovation & Efficiency: Implement Design of Experiments (DoE) and Quality by Design (QbD) principles to streamline development and ensure method robustness.

We are looking for a scientist who combines deep technical hands-on expertise with the strategic mindset required to thrive in a fast-paced CRO.

• PhD in Chemistry, Pharmacy, Biochemistry, or a related scientific field. Candidates with a Master’s degree and extensive, high-level industry experience in method development are also encouraged to apply.

• Technical Expertise

  • Expert-level knowledge of LC (HPLC/UPLC) and Mass Spectrometry (LC-MS/MS).

  • Proven experience working with "New Modalities": Oligonucleotides (IP-RP, AEX), Peptides, and Large Molecules (mAbs, proteins) is a plus.

  • Experience with Empower and Chromeleon

  • Familiarity with other separation techniques like Gas Chromatography (GC) and Capillary Electrophoresis (CE) is an advantage.

• Understanding of ICH Q14 principles and method validation according to ICH Q2 within GxP environments and a commitment to meticulous documentation.

• Knowledge of statistical tools and Design of Experiments (DoE) is a plus.

• You have the ability to look beyond the immediate test and understand the client's broader drug development goals.

• Comfortable managing multiple projects simultaneously in a dynamic, deadline-driven laboratory environment.

• Excellent command of English (written and spoken). Ability to translate complex data into clear reports and presentations for clients. Knowledge of Dutch is an asset.