Steviol glycosides are active components of Stevia extract, a well-known low-calorie sweetener. Steviol glycosides enhance taste and prevent the development of diet-induced diabetes in mice. We have previously shown that the interaction between steviol glycosides and the ion channel TRPM5 is essential for the biological effects of steviol glycosides. In the current project we aim to extend these findings to humans. The candidate will be involved in the design and execution of experiments which aim to show that steviol-glycosides are effective also in humans, with the clear objective to develop a novel type of therapy for type 2 Diabetes via modulation of the TRPM5 ion channel. The project will encompass in vitro and in vivo experiments, which will probe for functional effects of steviol glycosides in isolated cells and tissue(enhancement of insulin release, Ca2+ signalling in pancreatic ß cells,…) but also systemic effects in the living organism (glycemia, insulin resistance, taste perception,…).
More info on the project and the lab can be found here: